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Table 4 Comparison of characteristics at followed-up between sustained responder and recurrence

From: Recurrence risk factors for chronic hepatitis B virus-infected patients who achieve functional cure with pegylated interferon-α-2b-based therapy: a multicenter pilot study

Characteristic

Sustained responder group

Recurrence group

P value

Patients enrolled, n

85

16

 

Followed-up time (weeks)

72.00 (48.00, 96.00)

48.00 (48.00, 82.00)

0.124

HBsAg level (IU/ml)

< 0.05

0.54 (0.16, 2.01)

-

Anti-HBs positive, n (%)

50 (58.82%)

5 (31.25%)

0.042

Anti-HBs titer (mIU/ml)

31.00 (0.00, 295.3)

0.00 (0.00, 32.58)

0.011

Blood routine test

   

   White blood cells (×109/L)

3.48 (2.61, 4.72)

4.63 (3.82, 5.92)

0.004

   Neutrophils (×109/L)

2.01 (1.22, 2.72)

2.45 (2.19, 3.34)

0.014

   Platelets (×109/L)

153.1 ± 62.86

195.0 ± 50.90

0.023

   Red blood cells (×1012/L)

4.46 ± 0.71

4.87 ± 0.64

0.054

   Hemoglobin (g/L)

135.8 ± 22.42

147.8 ± 20.53

0.071

Liver function

   

   ALT (U/L)

23.00 (16.00, 38.00)

23.00 (18.00, 30.00)

0.670

   AST (U/L)

27.00 (20.50, 40.50)

20.00 (18.00, 31.00)

0.058

   T-BIL (µmol/L)

14.00 (11.40, 16.30)

15.20 (11.50, 19.25)

0.513

   Total protein (g/L)

73.73 ± 4.56

73.38 ± 4.75

0.713

   Albumin (g/L)

46.09 ± 3.53

45.52 ± 2.32

0.575

   Globulin (g/L)

27.68 ± 4.10

28.25 ± 3.97

0.649

  1. HBsAg: hepatitis B surface antigen; Anti-HBs: hepatitis B surface antibody; ALT: alanine aminotransferase; AST: aspartate aminotransferase; T-BIL: total bilirubin