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Table 1 Genome constellation and 50% egg infectious dose titers of Recombinant H5N1 viruses in embryonated chicken eggs (ECEs)

From: Intranasally administered whole virion inactivated vaccine against clade 2.3.4.4b H5N1 influenza virus with optimized antigen and increased cross-protection

Recombinant virus

HA

NA

PB2

PB1

PA

NP

M

NS

EID50/mLa

22W_PR8

22 W HAb

22 W NA

PR8

PR8

PR8

PR8

PR8

PR8

8.91 ± 0.14

22W_MVV

22 W HA

22 W NA

310-MVVc

PR8

PR8

PR8

PR8

PR8

9.91 ± 0.14 ***

22W_KY

22 W HA-R90K H110Yb

22 W NA

310-MVV

PR8

PR8

PR8

PR8

PR8

9.91 ± 0.14 ***

  1. a50% egg infectious dose (EID50/ml) of recombinant viruses harvested after inoculating 100 EID50 of each recombinant virus into 10-day-old SPF embryonated chicken eggs. The data are presented as the mean ± standard deviation (SD) of three independent experiments
  2. bThe HA cleavage site was attenuated from RERRRKR to ASGR
  3. cPB2 gene of A/chicken/Korea/01310/2001 (01310, H9N2) virus with I66M, I109V and I133V mutations
  4. *Significantly different from the virus titer of 22W_PR8 (***p < 0.001), Statistical significance was calculated by one-way ANOVA with Tukey’s multiple comparisons test
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Virology Journal

ISSN: 1743-422X