Fig. 2

EIDD-2801 protects mice from lethal co-infection of influenza A virus and influenza B virus. Mice co-infected with both H1N1-UI182 and IBV/S9-MD were monitored daily for clinical signs. A Body weight of infected mice. B Survival curves of infected mice. C Western Blot analysis of IAV M and IBV M protein expression in lung tissue homogenates (n = 5). The expression of β-actin was used as loading control D Representative images and photomicrographs of lung tissue (H&E staining) from mice co-infected with H1N1-UI182 and IBV/S9-MD. E Lung index of infected mice. F Histopathological scores of the lung tissues. G Viral titers in turbinates collected from euthanized mice at 5 dpi. Differences were considered significant at (**) 0.001 < P < 0.01, (***) P < 0.001, “ns” denotes no significance