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Fig. 3 | Virology Journal

Fig. 3

From: The first trimester human placenta responds to Zika virus infection inducing an interferon (IFN) and antiviral interferon stimulated gene (ISG) response

Fig. 3

ZIKV infection induces a Type III IFN response in first trimester placental explant tissue. Explant tissue was (A, B,C, D) infected with 107/ml ZIKV or (E, F,G, H) stimulated with 1 µg/ml poly(I: C)(A, B,C are n = 6 patients) (D, E,F, G,H are n = 4 patients). RNA was collected 24, 48, 72 and 96hpi followed by qRT-PCR analysis for the detection of IFNβ, IFNλ1 and IFNλ2/3. Data are normalised to the housekeeping gene RPLP0 and expressed as a fold-change relative to mock-infected control at each timepoint. (data are means ± SE) * P < 0.05, ** P < 0.01 ***< P0.005. Statistical analysis was performed on log transformed data at each time point using multiple unpaired T test for each gene

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Virology Journal

ISSN: 1743-422X