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Table 4 Clinical manifestations of patients with IEI virus infection and differences in clinical manifestations between groups

From: Characterization of the epidemiology, susceptibility genes and clinical features of viral infections among children with inborn immune errors: a retrospective study

Clinical manifestation

Total

n = 441

IEI_I

n = 115

IEI_II

n = 47

IEI_III

n = 102

IEI_IV

n = 26

IEI_V

n = 95

IEI_VI

n = 36

Others a

n = 18

p value

 Cough

314(71.20%)

100(87.07%)

32(68.09%)

65(63.73%)

15(59.26%)

67(70.53%)

22(61.11%)

11(61.11%)

0.001

 Enlarged lymph nodes

264(59.86%)

64(55.17%)

23(48.94%)

55(53.92%)

17(62.96%)

60(63.16%)

31(86.11%)

14(77.78%)

0.006

 Abnormal liver function

114(25.85%)

44(37.93%)

17(36.17%)

11(10.78%)

10(37.04%)

21(22.11%)

5(13.89%)

6(33.33%)

<0.001

 Fever

239(54.20%)

69(60.37%)

23(48.94%)

38(37.25%)

17(66.67%)

59(62.11%)

17(47.22%)

14(77.78%)

0.001

 Hepatomegaly

145(32.88%)

42(36.21%)

10(21.28%)

29(28.43%)

11(40.74%)

30(31.58%)

16(44.44%)

7(38.89%)

0.263

 Retinitis

38(8.62%)

19(16.38%)

6(12.77%)

1(0.98%)

1(7.41%)

7(7.37%)

1(2.78%)

2(11.11%)

0.002

 Splenomegaly

131(29.71%)

32(27.59%)

9(19.15%)

33(32.35%)

9(33.33%)

29(30.53%)

14(38.89%)

5(27.78%)

0.571

 Diarrhea

133(30.16%)

50(43.10%)

10(21.18%)

17(16.67%)

8(29.63%)

32(33.68%)

9(25.00%)

7(38.89%)

0.002

 Expectoration

163(36.96%)

48(41.38%)

18(38.30%)

40(39.22%)

7(29.63%)

34(35.79%)

10(27.78%)

5(27.78%)

0.627

 Dysplasia

39(8.84%)

8(6.90%)

7(14.89%)

13(12.75%)

3(11.11%)

4(4.21%)

2(5.56%)

2(11.11%)

0.245

  1. IEI, inborn errors of immunity. IEI_I, combined immunodeficiencies. IEI_II, combined immunodeficiencies with syndromic features. IEI_III, predominantly antibody deficiencies. IEI_IV,diseases of immune dysregulation. IEI_V, congenital defects of phagocytes. IEI_VI, defects in intrinsic and innate immunity. IEI_VII, autoinflammatory diseases. IEI_VIII, complement deficiencies. IEI_IX, bone marrow failure. IEI_X, phenocopies of inborn errors of immunity. a, sum of IEI_VII, IEI_VIII, IEI_IX and IEI_X