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Table 1 Demographic and epidemiological characterisation of viral infections in patients hospitalised with IEI during 2016-2022

From: Characterization of the epidemiology, susceptibility genes and clinical features of viral infections among children with inborn immune errors: a retrospective study

Characteristics

All patients

(N=931)

At least one virus infection (n=439)

Non-virus infection (n=492)

p value

Sex, male, n (%)

720 (77.34)

350 (79.73)

370 (75.20)

0.117

Age, month, median (IQR)

21 (6-71)

16 (5-54)

28 (9-84)

<0.001

Region, n (%)

   

0.889

 Eastern China

669 (71.86)

314(71.53)

355(72.15)

 

 Others

262(28.14)

125(28.34)

137 (27.96)

 

Age group, n (%)

   

<0.001

 Infant (birth to 1 year)

352(37.81)

195(44.42)

157(31.92)

 

 Toddler (1-3 years)

218(23.42)

104(23.69)

114(23.17)

 

 Preschooler (3-6 years)

130(13.96)

59(13.38)

71(14.49)

 

 Older child (6 -12 years)

155(16.65)

54(12.24)

101(20.61)

 

 Adolescent (12 -18 years)

76(8.16)

27(6.12)

49(10.00)

 

IEI categories, n (%)

   

<0.001

 IEI_I

180(19.33)

115(26.20)

65(13.21)

 

 IEI_II

96(10.31)

47(10.66)

49(10.00)

 

 IEI_III

274(29.43)

102(23.12)

172 (35.10)

 

 IEI_IV

46(4.94)

26(5.92)

20(4.07)

 

 IEI_V

214(22.99)

95(21.54)

119(24.29)

 

 IEI_VI

70(7.52)

36(8.16)

34(6.94)

 

 IEI_VII

43(4.62)

14(3.17)

29(5.92)

 

 IEI_VIII

1(0.11)

0(0)

1(0.20)

 

 IEI_IX

4(0.43)

2(0.45)

2(0.41)

 

 IEI_X

3(0.32)

2(0.45)

1(0.20)

 

Outcome, n (%)

   

0.006

 Death

35(3.76)

25(5.67)

10(2.04)

 
  1. Data are in n (percentage %) unless otherwise noted. Percentages may not total 100 due to rounding. IQR, interquartile spacing. IEI, inborn errors of immunity. IEI_I, combined immunodeficiencies. IEI_I, combined immunodeficiencies with syndromic features. IEI_III, predominantly antibody deficiencies. IEI_IV,diseases of immune dysregulation. IEI_V, congenital defects of phagocytes. IEI_VI, defects in intrinsic and innate immunity. IEI_VII, autoinflammatory diseases. IEI_VIII, complement deficiencies. IEI_IX, bone marrow failure. IEI_X, phenocopies of inborn errors of immunity