Fig. 1

Anti-RBD IgE antibody titers quantified using an in-house ELISA. Boxplots illustrate the distribution of peptide quantification. Whiskers extend 1.5 times the interquartile range (IQR) from each end of the box. Point-range symbols represent the adjusted group means of protein titers after statistical control for confounders, and their extension represents the 95% confidence intervals. These estimates were derived from a linear model and adjusted for sex, age and days from first clinical symptoms to sample extraction, in which Anti-RBD IgE antibody titer quantifications were transformed using the most suitable Box-Cox transformation with a lambda value of 0.25 in order to fulfill model assumptions. The red dashed line represents the threshold for ELISA positivity set to achieve a 95% assay specificity in the group of healthy controls