Fig. 6

Elevated IL-11 levels during BKPyV infection lead to increased activity of ERK and p90RSK. This results in GSK3β inactivation by phosphorylation of Thr43 and Ser9. This prevents GSK3β-mediated SNAI1 phosphorylation causing SNAI1 accumulation and the transcriptional suppression of its target genes, prototypically E-Cadherin which can lead to AKI