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Fig. 5 | Virology Journal

Fig. 5

From: BK Polyomavirus and acute kidney injury in transplant recipients: signaling pathways and molecular mechanisms

Fig. 5

During BKPyV infection, plenty of immune cells and cytokines are stimulated as the continuum cascades, including TNF-α that can enhance inflammation in human kidney cells by elevating IL-6 levels leading to elevation of DNMT1 to induce FOXO3a methylation and reduces FOXO3a expression. FOXO3a blocks the Wnt/β-catenin pathway to alleviate renal fibrosis in AKI

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Virology Journal

ISSN: 1743-422X